Сравнительный анализ радиосенсибилизирующего действия соединений, содержащих акридонуксусную кислоту, при проведении экспериментальной лучевой терапии злокачественных новообразований на модели метастатического колоректального рака у мышей линии balb/c

Александр Петрович Трашков; Арман Артушович Мужикян; Николай Васильевич Цыган; Александр Владимирович Рябцев; Анна Владимировна Рыбакова; Варвара Валерьевна Кванчиани; Алефтина Алексеевна Кравцова; Андрей Глебович Васильев

Сomparative analysis of acridineacetate-containing compounds’ radio-sensitizing effect during malignant tumor experimental radiotherapy in a metastatic colorectal cancer model in balb/c mice

Alexander P. Trashkov National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Peter the Great St. Petersburg Polytechnic University
Arman A. Muzhikyan National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Nikolay V. Tsygan National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Alexander V. Ryabtsev B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Anna V. Rybakova National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Varvara V. Kvanchiani B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Aleftina A. Kravtsova St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
Andrei G. Vasiliev St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Abstract

Radio-sensitizing compounds are used to increase radiotherapy effectivity and reduce negative pathologic systemic effects of radiation. These radio-sensitizers selectively pile-up in tumor tissue and enhance necrobiotic processes caused by irradiation. Unfortunately, broad introduction of radio-sensitizers into clinical practice is hampered by their low effectivity and substantial negative side effects. This what determines radio-sensitizers effectivity studies high actuality in a colorectal cancer mice model. The study involved 156 male BALB/c mice who had been transplanted with colorectal cancer. After the transplantation they were injected with acridineacetate – containing compounds Cyclopherone and Procitol. A comparative assessment was undertaken of tumor growth dynamics and metastatic rate. A combination of gamma-irradiation with radio-sensitizing compounds produces a more substantial therapeutic effect according to all parameters of the experimental colorectal cancer growth and development than the isolated effect of radiotherapy or antitumor drugs. A considerable slowing down of tumor growth on the 14^th and 28^th day of the study was revealed as well as a reliable inhibition of lymphogenous and hematogenous metastatic spread of neoplasma during the entire study and a statistically valid increase of lifespan of the experimental animals. The radiosensitizing effect of Procitol in combination with radiotherapy turned out to be more substantial than that of Cyclopherone.