Risk factors of progression of chronic kidney disease in children with congenital malformations of the urinary tract in the postoperative period

Rustem Z Ahmetshin; I Lutfarahmanov Ildar; Ivanovich Mironov Petr

Risk factors of progression of chronic kidney disease in children with congenital malformations of the urinary tract in the postoperative period

Rustem Z Ahmetshin Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation
I Lutfarahmanov Ildar Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation
Ivanovich Mironov Petr Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation

Abstract

The aim of the study is the identification of independent predictors of progression of chronic kidney disease (CKD) in children operated on for congenital malformations of the urinary tract (CMUT). Methods. Study design – retrospective, observational, cohort. Inclusion criteria were CMUT, glomerular filtration rate (GFR) <90 ml/min/1.73 m2. Age younger than 18 years of age. The study included 297 patients. Statistical processing of research results was carried out using the software package Statistica 6.0. and MedCalc (MedCalc Software, Belgium). Results. We identified that only glomerular filtration rate during the initial hospitalization (ОR = 9.40) and arterial hypertension (OR = 4.40) were independent predictors of CKD progression. The combination of these two variant showed the area under the ROC curve (0.756), significantly (p < 0.005) higher than the isolated value of these symptoms.