Measures in assessment of pediatric systemic lupus erythematosus

Ekaterina M Kuchinskaya; Mikhail M Kostik; Vyacheslav G Chasnyk

Measures in assessment of pediatric systemic lupus erythematosus

Ekaterina M Kuchinskaya St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Mikhail M Kostik St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Vyacheslav G Chasnyk St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation

Abstract

Systemic lupus erythematosus in children is aggressive disease with an unpredictable course and a more severe phenotype compared to adults. An appropriate monitoring of disease activity, damage and effectiveness of therapy is reqired. The first part of this artcle is review of indices and scales validated by international community for assessment of disease activity, flares, damage and response to therapy in clinical research, trials and usual clinical care; their strengths, restrictions and ability to detect changes are evaluated. We characterized different versions and modifications of standard indices, their advantages and disadvantages. Conclusion: The set of indices including ECLAM, SELENA-SLEDAI, SFI and Ped-SDI can be recommended for retrospective pediatric clinical studies, as they are simple for use and validated by international community.