Clinical characteristics of newborn with different birth weight (results of a multicenter cohort study)

  • Ivan A Deev Siberian State Medical University, Ministry of Healthcare of the Russian Federation
  • Kristina V Kulikova Siberian State Medical University, Ministry of Healthcare of the Russian Federation
  • Olga S Kobyakova Siberian State Medical University, Ministry of Healthcare of the Russian Federation
  • Evgeny S Kulikov Siberian State Medical University, Ministry of Healthcare of the Russian Federation
  • Aleksandr V Holopov Tomsk Region Health Department
  • Igor A Stepanov Regional Perinatal Center
  • Irina N Antonova Perm Regional Clinical Hospital
  • Elena G Bybchenko Regional Perinatal Center
  • Kirill E Holtzman St Nicholas Children’s Municipal Hospital No 17
  • Elena N Dorovskaja Trans-Baikal Regional Perinatal Center
  • Ekaterina N Kozhevnikova Regional Perinatal Center
  • Ludmila V Ledyakina Mordovia Republican Clinical Perinatal Center
  • Natalia A Makarova Trans-Baikal Regional Perinatal Center
  • Maria A Permyakova Perm Regional Clinical Hospital
  • Nadezhda G Popova Trans-Baikal Regional Perinatal Center
  • Anna A Stradina Mordovia Republican Clinical Perinatal Center
  • Larisa A Fedorova St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
  • Anna A Fomenko St Nicholas Children’s Municipal Hospital No 17
  • Ekaterina S Kharitonova St Nicholas Children’s Municipal Hospital No 17
  • Ekaterina B Khodosevich St Nicholas Children’s Municipal Hospital No 17
  • Irina N Chugainova Perm Regional Clinical Hospital

Abstract

This article is dedicated to analysis of clinical characteristics of children with different birth weight included in the multicenter cohort study of newborns. The study analyzed data 572 children who were stratified according to birth weight (normal, low, very low and extremely low body weight). As part of the protocol incorporating the patient’s visit was provided at the time of birth (visit 0), a retrospective collection of anamnestic data about the mother (Visit -1) and visit prospective study of children aged 12 months (Visit 1). As a result of the analysis, it was found that the increase in frequency of operative delivery, and reduction of Apgar score and the presence of the studied pathological conditions, to the greatest extent, common in children who had birth weight of less than 1500 in this case. The probability of a combination of 3 or more conditions (described in this paper), in the case of a child with an extremely low birth weight was higher in the 44-fold (OR = 44.52; CI95% 15,5-127,5), while when the newborn had very low birth weight - a chance of development was significantly higher only in the 7-fold (OR = 7.12; CI95% 2,4-20,9) compared with children who had a low birth weight. In this regard, there is a need not only to the use of modern technologies nursing of low birth weight infants, but also provide preventive care in a group of women with a high degree of perinatal risk and risk of preterm delivery, allowing prolong pregnancy up to 32 weeks and/or weight of the fruit body of more than 1000 g, which can improve the survival rates of patients and the prevention of premature severe disabling conditions in the future.