Генетические маркеры целиакии: современные представления

Ирина Николаевна Захарова; Татьяна Эдуардовна Боровик; Елена Александровна Рославцева; Елена Николаевна Касаткина; Юлия Андреевна Дмитриева

Genetic markers of celiac disease: modern concern

Irina Nikolayevna Zakharova Russian Medical Academy of Postgraduate Education
Tatyana Eduardovna Borovik Scientific Center of Children’s Health of Russian Academy of Medical Sciences
Yelena Aleksandrovna Roslavtseva Scientific Center of Children’s Health of Russian Academy of Medical Sciences
Yelena Nikolayevna Kasatkina Tushinskaya Children’s Hospital
Yuliya Andreyevna Dmitriyeva Russian Medical Academy of Postgraduate Education

Abstract

According to the results of recent scientific studies there is a strong evidence to characterize celiac disease as genetic disorder associated with antigens of major histocompatibility complex (MCH II) HLA-DQ2 and HLA-DQ8. Different loci of HLA molecules are encoded by specific alleles and their combination determines the individual risk of celiac disease formation. In this article authors discuss data on structure of DQ2 and DQ8 molecules, the frequency of different alleles detection in celiac patients and possible classification of genetic risk of celiac disease formation according to HLA-DQ genotype.