Clinical ambiguousness of measurement of tumor markers in the differential diagnosis of the uterus appendages tumors and inflam-matory pelvic mass in girls

In the diagnosis of ovarian tumors, with the most frequent gystotypes specific to childhood and adolescence, is widely used of tumor markers tests: alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and Ca-125. Features of the development of malignancies in children restrict of tumor markers tests in clinical practice. At the same time there are no tumor marker with 100 % specificity for the tumor. The article describes the clinical cases of 13-year-old female patient with appendicular infiltrate and secondary right adnekstumor and 14-year-old girl with hematogenous disseminated tuberculosis and salpingooophorities. The levels of Ca-125 and was an increased in both cases: in the first - to 39.41 IU/ml, in the second - up to 928.1 IU/ml. Thus, it was confirmed that the increase of serum concentration of CA-125 were in direct proportion to the pathological “irritation” of peritoneal serosa. In fact, the Ca-125 had the feature of acute phase proteins, so, its tumor specificity was low. Therefore the use of tumor marker test for Ca-125 is not always makes more easy task of differential diagnosis of the nature of the tumor mass pelvic in girls.