Оценка интервала Q–T у доношенных детей первого года жизни, перенесших задержку внутриутробного роста и развития легкой степени (поперечное исследование): ПЕРЕДОВАЯ СТАТЬЯ

Дмитрий Олегович  Иванов; Людмила Вячеславовна  Козлова; Лидия Ивановна  Ильенко; Виталий Викторович  Деревцов; Галина Александровна  Семашина

doi:10.56871/PED.2026.44.78.001

Evaluation of the Q–T interval in full-term infants with mild intrauterine growth and development delay (cross-sectional study)

EDITORIAL

Dmitry O. Ivanov Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-0060-4168
Lyudmila V. Kozlova Smolensk Regional Children’s Clinical Hospital https://orcid.org/0000-0003-0625-2877
Lidiya I. Ilyenko N.I. Pirogov Russian National Research Medical University https://orcid.org/0000-0001-8375-4569
Vitaly V. Derevtsov N.I. Pirogov Russian National Research Medical University https://orcid.org/0000-0002-8819-7033
Galina A. Semashina N.I. Pirogov Russian National Research Medical University https://orcid.org/0009-0008-8352-3793

Keywords:

delayed intrauterine growth and development children Q–T intervals Q–Тс Q–T1 T1–T задержка внутриутробного роста и развития дети интервалы Q–T Q–Тс Q–T1 T1–T

Abstract

Background.The implementation of fetal growth and development retardation mechanisms in postnatal ontogenesis in the form of the risk of total mortality and mortality from cardiovascular diseases has determined the relevance.

Aim—based on the assessment of theQ–Tinterval on the electrocardiogram in full-term infants who have suffered mild intrauterine growth restriction, in the dynamics of the first year of life, identify periods with an increased risk of changes in the cardiovascular system for early intervention and improvement of quality of life.

Materials and methods.139 children from singleton pregnancies from neonatal physiology departments were included. 114 were born to mothers with a history of fetal growth retardation (group 1, n=58) (hypotrophic (subgroup 1a, n=45) and hypoplastic (subgroup 1b, n=13) types) and without it (group 2, n=56). The control group consisted of practically healthy children born from the first birth through the natural birth canal to practically healthy mothers (group 3, n=25). 128 completed the study. The children were not subjected to medical intervention. Children’s observation points: 2–3 days, 1, 3, 6, 12 month. TheQ–Tinterval was measured and evaluated using nonparametric methods of statistical analysis, comparing the 95% confidence interval.

Results.No significant shortening of theQ–Tcinterval was found in the samples of group 1 at 3, 12 month, sub group 1a at 3 mo., subgroup 1b on days 2–3, at 1, 3, 6, 12 month. In the sample of subgroup 1b on days 2–3,Q–T1<Т1–Тwas 17 times more common compared to the situation whenQ–T1=Т1–Т; no dependencies were found at 3, 6 month, there was a violation of the ratio of the phases of electrical systole, there was no dependence ofQ–Tcand theQ–T1on the heart rate.

Conclusion.The periods with an increased risk of changes in the cardiovascular system in the sample of children of group 1 are 3 12 month, subgroup 1b — 2–3 days, 1, 3, 6, 12 month, subgroup 1a — 3 month.

Author Biographies

Dmitry O. Ivanov, Saint Petersburg State Pediatric Medical University

MD, Ph D, Dr Med Sci, Chief Freelance Neonatologist of the Ministry of Health of Russia, Rector, Head of the Department of Neonatology with courses of Neurology and Obstetrics and Gynecology of the Postgraduate and Additional Professional Education, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russia

Lyudmila V. Kozlova, Smolensk Regional Children’s Clinical Hospital

MD, Ph D, Dr Med Sci, Professor, Pediatrician, Pediatric Cardiologist, Neonatologist, Expert Advisor, Honored Doctor of the Russian Federation, Honored Scientist of the Russian Federation, President of the Smolensk Regional Union of Pediatricians of Russia, Smolensk Regional Children’s Clinical Hospital, Smolensk, Russia

Lidiya I. Ilyenko, N.I. Pirogov Russian National Research Medical University

MD, Ph D, Dr Med Sci, Professor, Head of the Department of Hospital Pediatrics № 2, Director of the Institute of Motherhood and Childhood, Honored Doctor of the Russian Federation, N.I. Pirogov Russian National Research Medical University, Moscow, Russia

Vitaly V. Derevtsov, N.I. Pirogov Russian National Research Medical University

MD, Ph D, Dr Med Sci, Associate Professor, Associate Professor of the Department of Hospital Pediatrics № 2, Institute of Motherhood and Childhood, N.I. Pirogov Russian National Research Medical University; address: 1, Building 6, Ostrovityanova str. , Moscow, 1117513, Russia

Galina A. Semashina, N.I. Pirogov Russian National Research Medical University

Assistant Professor, Department of Hospital Pediatrics No. 2, Institute of Motherhood and Childhood, Deputy Director of the Center for the Implementation of Educational Programs, N.I. Pirogov Russian National Research Medical University, Moscow, Russia

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