Оценка диагностической значимости определения концентрации сурфактантного белка D в сыворотке крови при внебольничной пневмонии у детей: ОРИГИНАЛЬНЫЕ СТАТЬИ

Наталья Анатольевна  Белых; Анастасия Юрьевна  Жулева; Наталья Александровна  Аникеева; Юлия Владимировна  Абаленихина; Александр Алексеевич  Никифоров; Лариса Владимировна  Никифорова; Владимир Владимирович  Горячев

doi:10.56871/PED.2026.16.68.003

Assessing the diagnostic utility of serum surfactant protein D concentration in childhood community-acquired pneumonia

ORIGINAL STUDIES

Nataliya A. Belykh Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0002-5533-0205
Anastasia Yu. Zhuleva Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0002-6926-2418
Nataliya A. Anikeeva Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0003-1103-2019
Yulia V. Abalenikhina Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0003-0427-0967
Alexander A. Nikiforov Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0001-9742-4528
Larisa V. Nikiforova Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0001-6296-9034
Vladimir V. Goryachev Ryazan State Medical University named after Academician I.P. Pavlov https://orcid.org/0000-0001-9555-6121

Keywords:

community-acquired pneumonia children surfactant protein D inflammatory biomarkers prognostic markers внебольничная пневмония дети сурфактантный белок D биомаркеры воспаления прогностические маркеры

Abstract

Background.Currently, there is a need to identify new biomarkers for assessing the severity of community-acquired pneumonia in children. Traditional diagnostic methods, which rely on the analysis of leukocyte counts, C-reactive protein levels, and procalcitonin levels, have limited predictive value due to the low specificity of these indicators. Surfactant protein D is produced by alveolar type II cells and reflects the degree of lung tissue damage.

The aim of the studywas to evaluate the diagnostic significance of serum surfactant protein D levels in children with community-acquired pneumonia of varying severity.

Materials and methods.The concentration of surfactant protein D in serum was measured using enzyme-linked immunosorbent assay in 65 children with community-acquired pneumonia and 31 healthy children. The participants were divided into three groups: 1st— patients with severe community-acquired pneumonia(n=20); 2nd— patients with non-severe community-acquired pneumonia (n=45); 3rd— control group (n=31).

Results.Serum surfactant protein D concentrations in children with community-acquired pneumonia significantly differed from those in the control group (p <0,0001). Statistically significant differences in serum surfactant protein D concentrations were recorded among children with community-acquired pneumonia depending on disease severity (p <0,0001). A set of significant correlations was identified between the serum surfactant protein D concentration and clinical indicators of disease severity, as well as the levels of other markers of systemic inflammation. It was found that serum surfactant protein D concentration has a higher discriminatory ability compared to standard laboratory markers (AUC=0,95, p <0,0001).

Conclusions.The findings indicate that surfactant protein D is involved in the development of the systemic inflammatory response in community-acquired pneumonia and demonstrate the advantages of measuring this marker for differentiating disease severity.

Author Biographies

Nataliya A. Belykh, Ryazan State Medical University named after Academician I.P. Pavlov

MD, Ph D, Dr Med Sci, Associate Professor, Head, Department of Faculty and Polyclinic Pediatrics, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

Anastasia Yu. Zhuleva, Ryazan State Medical University named after Academician I.P. Pavlov

Postgraduate Student, Department of Faculty and Polyclinic Pediatrics, Ryazan State Medical University named after Academician I.P. Pavlov; address: 9 Vysokovoltnaya str., Ryazan, 390026, Russia

Nataliya A. Anikeeva, Ryazan State Medical University named after Academician I.P. Pavlov

MD, Ph D, Associate Professor, Department of Faculty and Polyclinic Pediatrics, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

Yulia V. Abalenikhina, Ryazan State Medical University named after Academician I.P. Pavlov

MD, Ph D, Dr Med Sci, Leading Scientist, Laboratory for the Study of Pharmacokinetics of Medicinal Substances, Central Research Laboratory, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

Alexander A. Nikiforov, Ryazan State Medical University named after Academician I.P. Pavlov

MD, Ph D, Associate Professor, Head, Central Research Laboratory, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

Larisa V. Nikiforova, Ryazan State Medical University named after Academician I.P. Pavlov

Senior researcher, Central Research
Laboratory, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

Vladimir V. Goryachev, Ryazan State Medical University named after Academician I.P. Pavlov

Assistant Professor, Department
of Faculty and Polyclinic Pediatrics, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russia

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