Развитие фетоплацентарного комплекса у самок крыс в условиях неалкогольной жировой дистрофии печени: ОРИГИНАЛЬНЫЕ СТАТЬИ

Татьяна Георгиевна  Траль; Гулрухсор Хайбуллоевна  Толибова; Елена Витальевна  Мозговая; Марина Александровна  Крышня; Александра Александровна  Блаженко; Юлия Павловна  Милютина; Олеся Николаевна  Беспалова

doi:10.56871/PED.2026.26.32.005

Development of the fetoplacental complex in female rats under conditions of non-alcoholic fatty liver

ORIGINAL STUDIES

Tatiana G. Tral Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-8948-4811
Gulrukhsor Kh. Tolibova Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0002-6216-6220
Elena V. Mozgovaya Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0002-6460-6816
Marina A. Kryshnya Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0009-0000-2502-1578
Alexandra A. Blazhenko Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0002-8079-0991
Yulia P. Milyutina Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0003-1951-8312
Olesya N. Bespalova Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott https://orcid.org/0000-0002-6542-5953

Keywords:

non-alcoholic fatty liver disease histology placenta Heptrong неалкогольная жировая болезнь печени гистология плацента Гептронг

Abstract

Background.Obesity and its accompanying metabolic imbalance are a growing problem in modern society. Such changes in the mother’s body during pregnancy lead to pathology of placenta formation and negative perinatal outcomes. Despite a large number of studies in this field, there are still no unified approaches to correcting intrauterine changes in non-alcoholic fatty liver disease during pregnancy.

The aim to studythe effect of non-alcoholic fatty liver disease on the fetoplacental complex and the possibility of its correction in an experimental rat model.

Materials and methods.The study included 18 pregnant female rats, 12 females were simulated for non-alcoholic fatty liver disease through a high-calorie diet for 35 days. Animals were divided into three groups: without non-alcoholic fatty liver disease (n=6), with non-alcoholic fatty liver disease without therapy (n=6), and with low-molecular-weight sugar (Heptrong) therapy (n=6). After withdrawal from the experiment, a histological examination of the placentas of 30 fetuses was performed to assess the structural and circulatory characteristics.

Results.Histological changes in the structure of the placenta in non-alcoholic fatty liver disease with the formation of chronic placental insufficiency and vascular disorders, as well as with positive dynamics of the revealed changes during hepatoprotective therapy, were revealed.

Conclusion.The results of the study demonstrated the negative impact of metabolic disorders in non-alcoholic fatty liver disease with the formation of pathological changes in the structure of the placenta. The applied therapy contributed to the restoration of the structural components of the placenta of the offspring in the framework of the experiment.

Author Biographies

Tatiana G. Tral, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University

MD, Ph D, Dr Med Sci, Head of the Laboratory of Immunohistochemistry of the Pathology Department, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott; address: 3 Mendeleevskaya line, Saint Petersburg, 199034, Russia; Professor of the Department of Pathological Anatomy with a course in Forensic Medicine named after Professor D.D. Lokhov, Saint Petersburg State Pediatric Medical University; address: 2 Litovskaya str., Saint Petersburg, 194100, Russia

Gulrukhsor Kh. Tolibova, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

MD, Ph D, Dr Med Sci, Head of the Department of Pathomorphology, Research Institute ofObstetrics, Gynecology and Reproductology named after D.O. Ott,
Saint Petersburg, Russia

Elena V. Mozgovaya, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

MD, Ph D, Dr Med Sci, Leading Researcher at the Department of Obstetrics and Perinatology, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Marina A. Kryshnya, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

obstetrician-gynecologist at the Clinical Diagnostic Department, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Alexandra A. Blazhenko, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

MD, Ph D, Senior Researcher, Pharmacology Group, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Yulia P. Milyutina, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

Dr Bial Sci, Leading Researcher, Laboratory of Biochemistry with the Clinical and Diagnostic Department, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

Olesya N. Bespalova, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott

MD, Ph D, Dr Med Sci, Deputy Director for Scientific Work, Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

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