Pediatrician (St. Petersburg)

Modeling non-alcoholic fatty liver disease of different severity

ORIGINAL STUDIES

  • Tatiana V. Brus Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0001-7468-8563
  • Iren L. Galfanovich Saint Petersburg State Pediatric Medical University
  • Natalia A. Nudelman Saint Petersburg State Pediatric Medical University
  • Vladimir A. Evgrafov Saint Petersburg State Pediatric Medical University
  • Mariya Yu. Daineko Saint Petersburg State Pediatric Medical University
  • Irina I. Mogileva Saint Petersburg State Pediatric Medical University
  • Anastasiya V. Bannova V.I. Vernadsky Crimean Federal University https://orcid.org/0009-0007-6867-9477
  • Rodion V. Korablev Saint Petersburg State Pediatric Medical University
  • Sarng S. Pyurveev Saint Petersburg State Pediatric Medical University; Institute of Experimental Medicine https://orcid.org/0000-0002-4467-2269
  • Anna V. Vasilieva Saint Petersburg State Pediatric Medical University
  • Andrei G. Vasiliev Saint Petersburg State Pediatric Medical University https://orcid.org/0000-0002-8539-7128
  • Lyudmila M. Tyumina Saint Petersburg State Pediatric Medical University
Keywords:
non-alcoholic fatty liver disease hepatitis hepatic steatosis metabolism неалкогольная жировая болезнь печени гепатит стеатоз печени метаболизм

Abstract

BACKGROUND: One of the priority areas of modern medicine, which unites the interests of various specialists (therapists, cardiologists, gastroenterologists, endocrinologists), is the study of the pathogenesis and clinical manifestations of non-alcoholic fatty liver disease, which is widespread and of unconditional social significance. A search for non-alcoholic fatty liver disease adequate experimental model is of utmost importance for the studies of its etiology and pathogenesis. To understand all pathogenetic peculiarities of this pathology elaboration of hypercaloric hepatopathogenic diet rich in carbohydrates model is of utmost interest.

AIM: The aim of the study was to assess biochemical profile changes including antioxidant system significant markers in rat fructose-induced non-alcoholic fatty liver disease model.

MATERIALS AND METHODS: Two non-alcoholic fatty liver disease model versions were used: a light one — non-alcoholic steatosis and a severe variant — non-alcoholic steatohepatitis.

RESULTS: Both were characteristic of bilirubinemia, cholesterolemia, lipid peroxidation activation and antioxidation mechanisms suppression, cytolitic and cholestatic syndromes.

CONCLUSIONS: The extent of metabolic disorders proved to depend on non-alcoholic fatty liver disease model severity.

Author Biographies

Tatiana V. Brus, Saint Petersburg State Pediatric Medical University

MD, Ph D, Associate Professor, Department of Pathological Physiology with a Course of Immunopathology, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation; address: 2 Litovskaya St., Saint Petersburg, 194100, Russia

Iren L. Galfanovich, Saint Petersburg State Pediatric Medical University

Senior Lecturer, Department of Foreign
Languages with courses in Russian and Latin, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Natalia A. Nudelman, Saint Petersburg State Pediatric Medical University

Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Vladimir A. Evgrafov, Saint Petersburg State Pediatric Medical University

MD, Ph D, Associate Professor, Department of Anesthesiology, Resuscitation and Emergency Pediatrics named after Professor V.I. Gordeev, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Mariya Yu. Daineko, Saint Petersburg State Pediatric Medical University

Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Irina I. Mogileva, Saint Petersburg State Pediatric Medical University

Ph D, Associate Professor, Head of the Department of Foreign Languages with courses in Russian and Latin, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Anastasiya V. Bannova, V.I. Vernadsky Crimean Federal University

2nd year student of 1st medical faculty, S.I. Georgievsky Order of the Red Banner of Labor Medical Institute, V.I. Vernadsky Crimean Federal University, Simferopol, Russia

Rodion V. Korablev, Saint Petersburg State Pediatric Medical University

MD, Ph D, Associate Professor, Department of Pathological Physiology with a Course of Immunopathology, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Sarng S. Pyurveev, Saint Petersburg State Pediatric Medical University; Institute of Experimental Medicine

MD, Ph D, Assistant Professor, Department of Pathological Physiology with the Course of Immunopathology, Saint Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia; Research Associate, Department of Neuropharmacology,
Institute of Experimental Medicine, Saint Petersburg, Russia

Anna V. Vasilieva, Saint Petersburg State Pediatric Medical University

Assistant Professor, Department of Pathological Physiology with a Course of Immunopathology, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Andrei G. Vasiliev, Saint Petersburg State Pediatric Medical University

MD, Ph D, Dr. Sci. (Medicine), Professor, Head of the Department of Pathological Physiology with a Course in Immunology, Saint Petersburg State Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

Lyudmila M. Tyumina, Saint Petersburg State Pediatric Medical University

Senior Lecturer, Department of Foreign Languages with courses in Russian and Latin, Saint Petersburg State Pediatric Medical Pediatric University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia

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Issue
Vol. 16 No. 1 (2025)
Section
ORIGINAL STUDIES
Published
2026-09-10