Исследование сероводорода в пуповинной крови для прогнозирования функционирования артериального протока у глубоконедоношенных новорожденных

Наталья Валерьевна Харламова; Юлия Андреевна Фисюк; Ольга Григорьевна Ситникова; Татьяна Зиновьевна Горожанина; Сергей Борисович Назаров

The study of hydrogen sulfide in cord blood to predict the functioning of the ductus arteriosus in preterm infants

Natalya V. Kharlamova Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Julia A. Fisuk Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Olga G. Sitnikova Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Tatiana Z. Gorozhanina Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation
Sergey B. Nazarov Ivanovo Research Institute of Motherhood and Childhood named after VN. Gorodkov, Ministry of Health of the Russian Federation

Abstract

The hemodynamically significant functioning ductus arteriosus in premature infants can cause many complications and worsen the prognosis for life and health. Therefore, the determination of a high risk of the functioning of the ductus arteriosus is an urgent problem of the early neonatal period. Characteristic echocardiographic manifestations of a functioning ductus arteriosus is a lower stroke volume, higher pressure in the pulmonary artery and aorta. In the framework of this study, the frequency of the functioning ductus arteriosus in deeply premature infants was revealed. It was found that the concentration of hydrogen sulfide in umbilical cord blood in lower preterm infants with a functioning arterial duct is lower than in newborns without a functioning arterial duct. It is shown that the concentration of hydrogen sulfide in cord blood can be used for early detection of this condition. A method for predicting the functioning of the arterial duct has been developed, which consists in calculating the prognostic index D taking into account the gestational age, weight and height of the newborn, as well as the concentration of hydrogen sulfide in cord blood.